Research
Dr. Dij is an award-winning cancer researcher with 20 years of experience and expertise in integrative genomics, integrative epigenomics, and molecular epidemiology.
Through impactful cancer health disparities research articles in journals such as Nature Communications, Nature Cancer, Journal of Thoracic Oncology, and Clinical Cancer Research, Dr. Dij and her collaborators have identified micro-geographic contributors to lung cancer incidence, and shown clinically-relevant genomic, transcriptomic, and proteomic differences exist between lung and kidney cancers from African Americans and European Americans.
Currently, her research group is exploring how the exposome (e.g. cigarette smoking and radon exposure) influences lung cancer risk, lung cancer biology, and patient response to therapy. Visit the Lab page if you are interested in learning more or joining the laboratory family.
REFERENCES
Research Articles
11. 2022 Mitchell K.A., Williams H.
Emerging genomic biomarkers for improving kidney, prostate, and bladder cancer health disparities outcomes, Urologic Oncology: Seminars and Original Investigations, doi: 10.1016/j.urolonc.2019.04.024, PMID: 31239186
10. 2021 Zingone, A., Sinha, S., Ante, M., Nguyen, C., Daujotyte, D., Bowman, E. D., Sinha, N., Mitchell, K. A., Chen, Q., Yan, C., Loher, P., Meerzaman, D., Ruppin, E., & Ryan, B. M.
A comprehensive map of alternative polyadenylation in African American and European American lung cancer patients. Nature Communications, doi: https://doi.org/10.1038/s41467-021-25763-5, PMID: 34556645
9. 2020 Arauz R.F., Byun J.S., Tandon M., Sinha S., Kuhn S., Taylor S., Zingone A., Mitchell K.A., Pine S.R., Gardner K., Perez-Stable E.J., Napoles A.M., Ryan B.M.
Whole Exome Profiling of Lung Cancer Among African Americans, Journal of Thoracic Oncology, doi: 10.1016/j.jtho.2020.08.029, PMID: 32931935
8. 2020 Sinha S., Mitchell K.A., Zingone A., Bowman E., Sinha N., Schäffer A.A., Lee J.S., Ruppin E., Ryan B.M.
Higher prevalence of homologous recombination deficiency in tumors from African Americans versus European Americans, Nature Cancer, doi: 10.1038/s43018-019-0009-7, PMID: 35121843
7. 2019 Mitchell K.A.*, Nichols N.*, Tang W., Walling J., Stevenson H., Pineda M., Stefanescu R.,
Edelman D.C., Girvin A.T., Zingone A., Sinha S., Bowman E., Rossi E., Arauz R.F., Zhu Y.J., Lack J., Weingartner E., Waterfall J., Pine S., Simmons J., Meltzer P., Ryan B.M.
*Authors contributed equally
Recurrent PTPRT/JAK2 Mutations in Lung Adenocarcinoma among African Americans, Nature Communications, doi: 10.1038/s41467-020-14448-0, PMID: 31844068
6. 2019 Mitchell K.A., Shah E. , Bowman E., Zingone A., Nichols N., Pine S.R., Kittles R., Ryan B.M.
Relationship between West African Ancestry and Lung Cancer Risk Survival in African
Americans, Cancer Causes Control, doi: 10.1007/s10552-019-01212-z, PMID: 31468279
5. 2019 Meaney C.*, Mitchell K.A.*, Zingone A., Brown D., Yu Y., Wenzlaff A.S., Pine S., Cao L.,
Schwartz A.G., Ryan B.M.
*Authors contributed equally
Circulating Inflammation Proteins Associated with Lung Cancer in African Americans, Journal of Thoracic Oncology, doi: 10.1016/j.jtho.2019.03.014, PMID: 30953795
4. 2018 Erickson P., Gardner L.D., Loffredo C.A., St. George DM, Bowman E.D., Deepak J,
Mitchell K.A., Meaney C.L., Langenberg P., Bernat D., Am S., Ryan B.M.
Racial and Ethnic Differences in the Relationship Between Aspirin Use and Non-Small Cell
Lung Cancer Risk and Survival, Cancer Epidemiology, Biomarkers & Prevention, doi: 10.1158/1055-9965.EPI-18-0366, PMID: 30171037
3. 2018 Nichols N., Mitchell K.A., Zingone A., Meaney C., Bowman E.D., Ryan B.M.
Relationship between the TP53 SNP rs1800371 and Lung Cancer in African Americans, Cancer Health Disparities, doi:10.9777/chd.2018.10016
2. 2018 Houston K.A., Mitchell K.A., King J., White A., Ryan B.M.
Histologic Lung Cancer Incidence Rates and Trends Vary by Race/Ethnicity and Residential County, Journal of Thoracic Oncology, doi: 10.1016/j.jtho.2017.12.010, PMID: 29360512
1. 2017 Mitchell K.A., Zingone A., Toulabi L., Boeckelman J., Ryan B.M.
Comparative Transcriptome Profiling Reveals Clinically Relevant Coding and Non-Coding RNA Differences in NSCLC from African Americans and European Americans,
Clinical Cancer Research, doi: 10.1158/1078-0432.CCR-17-0527, PMID: 29196495
Through impactful cancer health disparities research articles in journals such as Nature Communications, Nature Cancer, Journal of Thoracic Oncology, and Clinical Cancer Research, Dr. Dij and her collaborators have identified micro-geographic contributors to lung cancer incidence, and shown clinically-relevant genomic, transcriptomic, and proteomic differences exist between lung and kidney cancers from African Americans and European Americans.
Currently, her research group is exploring how the exposome (e.g. cigarette smoking and radon exposure) influences lung cancer risk, lung cancer biology, and patient response to therapy. Visit the Lab page if you are interested in learning more or joining the laboratory family.
REFERENCES
Research Articles
11. 2022 Mitchell K.A., Williams H.
Emerging genomic biomarkers for improving kidney, prostate, and bladder cancer health disparities outcomes, Urologic Oncology: Seminars and Original Investigations, doi: 10.1016/j.urolonc.2019.04.024, PMID: 31239186
10. 2021 Zingone, A., Sinha, S., Ante, M., Nguyen, C., Daujotyte, D., Bowman, E. D., Sinha, N., Mitchell, K. A., Chen, Q., Yan, C., Loher, P., Meerzaman, D., Ruppin, E., & Ryan, B. M.
A comprehensive map of alternative polyadenylation in African American and European American lung cancer patients. Nature Communications, doi: https://doi.org/10.1038/s41467-021-25763-5, PMID: 34556645
9. 2020 Arauz R.F., Byun J.S., Tandon M., Sinha S., Kuhn S., Taylor S., Zingone A., Mitchell K.A., Pine S.R., Gardner K., Perez-Stable E.J., Napoles A.M., Ryan B.M.
Whole Exome Profiling of Lung Cancer Among African Americans, Journal of Thoracic Oncology, doi: 10.1016/j.jtho.2020.08.029, PMID: 32931935
8. 2020 Sinha S., Mitchell K.A., Zingone A., Bowman E., Sinha N., Schäffer A.A., Lee J.S., Ruppin E., Ryan B.M.
Higher prevalence of homologous recombination deficiency in tumors from African Americans versus European Americans, Nature Cancer, doi: 10.1038/s43018-019-0009-7, PMID: 35121843
7. 2019 Mitchell K.A.*, Nichols N.*, Tang W., Walling J., Stevenson H., Pineda M., Stefanescu R.,
Edelman D.C., Girvin A.T., Zingone A., Sinha S., Bowman E., Rossi E., Arauz R.F., Zhu Y.J., Lack J., Weingartner E., Waterfall J., Pine S., Simmons J., Meltzer P., Ryan B.M.
*Authors contributed equally
Recurrent PTPRT/JAK2 Mutations in Lung Adenocarcinoma among African Americans, Nature Communications, doi: 10.1038/s41467-020-14448-0, PMID: 31844068
6. 2019 Mitchell K.A., Shah E. , Bowman E., Zingone A., Nichols N., Pine S.R., Kittles R., Ryan B.M.
Relationship between West African Ancestry and Lung Cancer Risk Survival in African
Americans, Cancer Causes Control, doi: 10.1007/s10552-019-01212-z, PMID: 31468279
5. 2019 Meaney C.*, Mitchell K.A.*, Zingone A., Brown D., Yu Y., Wenzlaff A.S., Pine S., Cao L.,
Schwartz A.G., Ryan B.M.
*Authors contributed equally
Circulating Inflammation Proteins Associated with Lung Cancer in African Americans, Journal of Thoracic Oncology, doi: 10.1016/j.jtho.2019.03.014, PMID: 30953795
4. 2018 Erickson P., Gardner L.D., Loffredo C.A., St. George DM, Bowman E.D., Deepak J,
Mitchell K.A., Meaney C.L., Langenberg P., Bernat D., Am S., Ryan B.M.
Racial and Ethnic Differences in the Relationship Between Aspirin Use and Non-Small Cell
Lung Cancer Risk and Survival, Cancer Epidemiology, Biomarkers & Prevention, doi: 10.1158/1055-9965.EPI-18-0366, PMID: 30171037
3. 2018 Nichols N., Mitchell K.A., Zingone A., Meaney C., Bowman E.D., Ryan B.M.
Relationship between the TP53 SNP rs1800371 and Lung Cancer in African Americans, Cancer Health Disparities, doi:10.9777/chd.2018.10016
2. 2018 Houston K.A., Mitchell K.A., King J., White A., Ryan B.M.
Histologic Lung Cancer Incidence Rates and Trends Vary by Race/Ethnicity and Residential County, Journal of Thoracic Oncology, doi: 10.1016/j.jtho.2017.12.010, PMID: 29360512
1. 2017 Mitchell K.A., Zingone A., Toulabi L., Boeckelman J., Ryan B.M.
Comparative Transcriptome Profiling Reveals Clinically Relevant Coding and Non-Coding RNA Differences in NSCLC from African Americans and European Americans,
Clinical Cancer Research, doi: 10.1158/1078-0432.CCR-17-0527, PMID: 29196495
